ToeJam & Earl in Panic on Funkotron is a platform video game that serves as the sequel to the original ToeJam & Earl. Released in 1993, this title features two alien protagonists who return to their home planet only to find Earthlings causing chaos. The gameplay revolves around capturing these Earthlings and imprisoning them in jars, marking a significant shift from the treasure hunt mechanics of its predecessor. The game is notable for its colorful graphics, engaging soundtrack, and smooth action, including a cooperative two-player mode that enhances the overall experience.

While the game was well-received critically and commercially, it faced mixed reactions from fans due to its departure from the original's gameplay style. Some players appreciated the changes, while others felt the sequel strayed too far from what made the first game a classic. Despite the divided opinions, ToeJam & Earl in Panic on Funkotron remains a key title in the Mega Drive's catalog, influencing later installments and retaining a place in gaming history.