Serious Sam: Kamikaze Attack is an action-packed 2D game for iPhone where players assume the role of a Beheaded Kamikaze. The main objective is to chase down Serious Sam while avoiding his deadly arsenal, which includes a rocket launcher and Serious Bombs. Players must skillfully navigate the environment, utilizing jumps and kicks to deflect projectiles. The game features a unique rage meter that adds an extra layer of strategy; kicking projectiles increases the meter, and if it maxes out, the Kamikaze will explode, losing a life. With a point system rewarding players for successful maneuvers, the gameplay is both challenging and engaging.

The game offers various levels set in diverse environments like deserts and forests, along with special challenge levels for seasoned players seeking additional difficulty. Players can enhance their experience by purchasing different heads for the Kamikaze, each impacting gameplay attributes and representing characters from the Serious Sam series. This adds a customizable element, allowing players to tailor their gaming experience while enjoying the frantic action.