Serious Sam: Kamikaze Attack is a dynamic 2D action game available on Android, where players control a Beheaded Kamikaze character in a thrilling chase against Serious Sam. The gameplay revolves around dodging projectiles launched by Sam, who wields powerful weapons like rocket launchers and Serious Bombs. Players must skillfully jump and kick projectiles to survive while managing a rage meter that can lead to explosive consequences if it fills up. Completing levels rewards players with points for various achievements, including successfully returning projectiles and defeating the formidable Sam.

The game features diverse environments, including deserts and forests, along with specialized challenge levels that provide additional gameplay for those seeking extra difficulty. Players can enhance their experience by purchasing and equipping unique heads for their Kamikaze, which modify gameplay mechanics, such as reducing penalties from kicking projectiles. These heads pay homage to iconic characters from the Serious Sam series, adding a layer of customization to the game.