Rogue City Scavenger immerses players in a challenging roguelike experience where they embody a government agent tasked with uncovering the origin of a lethal disease plaguing the city. From the onset, players find themselves trapped with an enigmatic alien entity, setting the stage for a perilous journey where survival is anything but guaranteed.

Navigating through the treacherous cityscape, players engage in turn-based combat, maneuvering strategically to evade threats, explore buildings, confront diverse adversaries, and deploy an array of weaponry. With a steep learning curve that may require multiple restarts, the game gradually unfolds into a gripping narrative, promising a rewarding experience for persistent players.