Quadropus Rampage is an unconventional 'roguelike' game that breaks away from traditional concepts to offer a frantic and accessible gameplay experience. Players take control of an octopus armed with a sword, battling various sea creatures at the bottom of the ocean to earn experience and level up. The game draws comparisons to the popular title The Binding of Isaac for its engaging mechanics.

Enemies defeated in Quadropus Rampage drop a variety of weapons, including anchors, giant fish bones, and hammers, adding a layer of strategy to the gameplay. With three attack types - normal, ink propulsion, and special attacks - players can unleash powerful moves to decimate hordes of enemies. The game's colorful graphics set it apart from typical roguelike aesthetics, enhancing the overall immersive experience.