PatientZ: Survivalist is an immersive action game set in a post-apocalyptic world, designed for single-player, co-op, and multiplayer gameplay. Players can utilize a variety of vehicles, including quad bikes, bicycles, and cars, to traverse the landscape quickly. The game features a basic crafting system, allowing players to create weapon variations and essential items to aid in their survival. Dynamic item spawns encourage exploration as players search for weapons and resources in logical and unexpected locations.

The game emphasizes character persistence, with stats and inventory saved upon exit, ensuring a seamless return to gameplay. Players must manage their food and water levels to maintain performance, while also navigating a free-for-all PvP environment where loot can be stolen upon death. With full day/night cycles and both first and third-person camera views, PatientZ: Survivalist aims to provide a rich and engaging survival experience.