Oxygen Not Included: Spaced Out is a simulation game that expands the original experience of colony management into space. Players will engage in space missions to explore new Planetoids, where they will need to manage resources and maintain the well-being of their Duplicants across multiple colonies. The game emphasizes real-time multi-world gameplay, allowing players to switch between planets and gather rare resources essential for the growth and sustainability of their home base.

The expansion introduces enhanced rocketry features, enabling players to customize modular rockets and navigate through an updated Starmap. With an expanded research tree, players can unlock new technologies that enhance their strategic options in a competitive asteroid environment. Additionally, new critters, biomes, and resources enrich the gameplay, providing a vast universe to explore and conquer, making it a compelling addition to the simulation genre.