Lost Labyrinth DX is a traditional roguelike game where players delve into procedurally-generated dungeons, aiming to progress as far as possible before meeting their demise by a monster or trap. Games typically last between 15 to 30 minutes, offering quick and intense gameplay sessions. Players can select from a wide array of skills to customize their hero, enabling diverse character builds such as archmages, barbarians, paladins, and rogues.

In Lost Labyrinth DX, character progression differs from typical roguelikes as experience is gained by advancing through levels rather than defeating enemies. This unique mechanic encourages strategic gameplay, where dodging enemies can be as valuable as engaging them. With a vast selection of skills and spells available, players can continually enhance their abilities by exploring deeper into the dungeon.