Hydrophobia: Prophecy is an action-adventure game with elements of survival horror in the cyberpunk style. The game takes place in the middle of the XXI century, where the world is plunged into chaos caused by overpopulation. The game takes place on board a giant cruise liner called the Queen of the World, built to create comfortable conditions for the elected representatives from among the managers of giant corporations.

The protagonist, system engineer Kate Wilson, is responsible for the safety of the liner, but when a group of terrorists attack and seize the ship, Kate must seek to survive and prevent the terrorists from killing billions of people. Hydrophobia: Prophecy's gameplay is centered on the player against the environment, with water constantly changing the configuration of spaces suitable for action and movement.