Wanderer of Lifetimes is a role-playing game that takes players on a journey through lifetimes in an Eastern-inspired land, where the cycle of karma governs the rules of life and death. The game's main objective is to complete a mission that will decide the fate of the world, and players must achieve it over many lifetimes.

The game features a mix of text-adventure style narrative with 2D exploration and stamina-based combat. The game takes place in both the living world and the afterlife, with unique mechanics and adjustments available only in the afterlife. Players can spend karma accrued in life to acquire permanent power-ups/abilities and apply temporary boons to improve their chances of success in the next life. The game's karma system encourages players to find new approaches to challenges after experiencing failure.