Viscera Cleanup Detail: Santa's Rampage is a science-fiction game that takes place after an alien invasion on a space station. Players take on the role of a space janitor, tasked with cleaning up the aftermath of the battle between the aliens and earthlings. The game requires players to collect and dispose of various types of garbage, from bullet casings and broken glass to body parts and medicine.

The gameplay involves using tools such as a mop, a device for detecting biological remains, and a PDA to interact with the garbage. The game offers a unique challenge as players must think about their actions to avoid creating more mess.