The renowned scientist in charge of Project TubeTwist has gone missing! In an attempt to find the professor, you must reconstruct her experiments and solve the mystery of her mysterious disappearance.

The overall goal of the game is to construct a machine that will guide the professors' famous Macroton devices from their starting positions to a final reactor tube where their energy will be extracted and stored for later use. Over thirty different tubes of various shapes and sizes must be combined to complete the machines including spirals, switches, anti-gravity devices, twisty turns, and precipitous drops.

TubeTwist is a puzzle game fashioned after classics like The Incredible Machine and Mouse Trap. Each experiment has many solutions due to the large variety of tubes which can be used to construct each machine. There is no clock and there is no score - so just sit back and enjoy the mind bending fun that is TubeTwist!