Trail of Nen is a story of a 12-year-old boy on an adventure looking for his father. Along the way, he will have to overcome many different enemies, including other people, wild animals, and even large and dangerous bosses.

The gameplay consists of traveling across the different worlds and finding various items and enemies. The main enemies are the bosses, which are also divided into different groups. At each world, the player will have to find the boss and defeat him in order to advance to the next world.

In order to defeat the bosses, the player will have to use various items and strategies.