The game takes place in the world of Gensokyo, which is home to many different supernatural beings. In this world, there are monsters known as Gods, Youkai, Vampires, and other supernatural beings. These beings are said to be able to control the actions of humans.

Touhou LostWord is a RPG game in which you use your characters' Spell Cards to fight in exciting bullet hell battles. Utilize some of the world's most beloved Touhou characters including Sanae, Marisa and Cirno. Use your party's unique abilities and climb all 100 floors of Scarlet Devil Tower!