Tota Life: Hospital offers an immersive experience centered around a hospital setting. Players can explore various departments, taking on roles as doctors and patients interchangeably. With a hospital spanning four floors and a dressup hall, the game provides a unique blend of simulation and creativity. From managing a pharmacy to attending to patients in the emergency room, the gameplay offers diverse scenarios to engage with.

On the second floor, players can delve into eye and dental check-ups, emphasizing the importance of health. Additionally, the game introduces elements of caregiving, with tasks like assisting a pregnant character and nurturing a newborn baby. The Dress Up Hall feature allows players to customize characters and create unique relationships, adding a personal touch to the gameplay.