According to the game story, the first Speedball league (founded in 2095) fails due to violence and corruption. As the organization gave place to anarchy, the game is forced underground, but five years later, from one attempt to regain public interest, Speedball 2 is born. The game starts in 2105 as a new team Brutal Deluxe emerges.

Speedball 2 is one of Bitmap Brothers' most successful titles and was released for several platforms including the Amiga, CD 32, Acorn Archimedes, IBM-PC, Atari ST, Commodore 64, Sega Mega Drive/Genesis, Master System, Game Boy and the Game Boy Advance. The first version was released in 1991, the final version ten years later.

Changes were made to the rules of the game, meaning that teams have 9 players on court rather than 6, and targets on the floor and walls can be hit for bonus points. The music, written by Simon Rogers and remixed and coded by Richard Joseph won the Golden Joystick award for best soundtrack.