Section 13 is a roguelite twin-stick shooter designed for Xbox Series X|S, offering both solo and cooperative gameplay for up to three players. Players assume the role of Agents from the S2P Corporation, tasked with uncovering the mysteries surrounding a containment breach at a secret facility. The game emphasizes exploration and tactical combat against paranormal entities, allowing players to collect data and confront personal challenges throughout their journey.

The gameplay features intense action with customizable weapons and unique abilities, encouraging players to strategize against a variety of foes. A notable aspect of Section 13 is its fear mechanic, where players must manage their Fear level to avoid panic attacks during missions. With a range of unlockable upgrades and enhancements, each run offers fresh challenges and opportunities for players to adapt their strategies as they delve deeper into the enigmatic and hazardous environment.