Saint Seiya: Death and Rebirth is a beat'em up game where players assume the roles of the five main knights of the zodiac, engaging in an adventurous journey across numerous scenes while battling various enemy knights. The game features a story mode reminiscent of manga and anime narratives, pitting players against dark knights like Ikki, the Phoenix knight, in addition to other compelling plotlines.

Each character in Saint Seiya: Death and Rebirth possesses distinct attacks and special moves inspired by the anime series. For instance, Hyoga freezes foes with ice attacks, and Seiya can briefly invoke the Sagittarius armor for protection. Developed using OpenBor, this beat'em up game offers a rich storyline, incorporates video scenes from the original cartoon, and provides enjoyable gameplay for up to three players simultaneously.