PRAN Guías, part of the National Health System's Antimicrobial Therapeutic Guide, is an application developed under the National Plan against Antibiotic Resistance (PRAN). Its primary aim is to standardize and optimize antibiotic treatment prescriptions to minimize the risk of resistance development. The guide offers recommendations for managing prevalent infectious processes in adults, children, and patients in sociosanitary centers. It is evidence-based, includes resistance pattern guidance, addresses antimicrobial usage in special situations like renal or hepatic insufficiency, pregnancy, lactation, overweight, and obesity, provides a manual for microbiological sample collection, and discusses deferred antibiotic prescription considerations. Targeted at healthcare professionals in Primary Care, Pediatrics, Emergency, Dentistry, and sociosanitary centers.