Plague Doctor: Life in Pestilence is a simulation game that immerses players in the historical context of the plague era. Set in a detailed environment, players start as an unknown quack and aim to become a reputable Plague Doctor. The game features various mechanics such as gathering ingredients, brewing remedies, and expanding your clinic. Players can engage in surgeries and manage their resources effectively to save patients or let them succumb to the disease.

The game supports both solo play and cooperative gameplay for up to four players, allowing friends to join in the experience. Players face moral choices as they decide whether to uphold the Hippocratic Oath or to watch society crumble amidst the plague. With its engaging gameplay and historical elements, Plague Doctor: Life in Pestilence offers an intriguing simulation experience.