にじいろLive is an exciting game set in a world where mysterious monsters called "プカ" have suddenly appeared all over the globe. These monsters cannot be defeated with conventional weapons, causing chaos worldwide. However, it has been discovered that special weapons utilizing the psychic powers of a select few humans are effective against the "プカ."

Interestingly, most of the individuals who can wield these special weapons are young girls, predominantly under the age of twenty. Recognizing the existence of these girls with extraordinary powers, governments around the world have gathered them in specialized academies to provide protection and training.

To fully unleash the girls' abilities, the care of their mental and emotional well-being is crucial. The academy is in need of talented individuals who can bring out the potential of these sensitive and lovely girls.

Earn the trust of the girls and take on the incredible challenge of the "プカ" for the sake of humanity!

"Teacher, please make sure to watch over me!" the girls say.