Neighbours from Hell 2: On Vacation is a strategy game where players engage in humorous pranks against a troublesome neighbor. Set on a cruise liner, players join Woody and the camera crew as they embark on a mission to make the neighbor’s vacation miserable. The game introduces new dynamics with the neighbor's mother accompanying him, adding an extra layer of challenge as players must navigate her protective instincts while executing their mischievous plans.

The gameplay involves strategically planning and executing various tricks to annoy the neighbor and fellow travelers, ensuring that players think creatively to achieve their goals. With its engaging storyline and entertaining mechanics, Neighbours from Hell 2 provides a unique blend of strategy and humor, appealing to fans of the genre looking for a lighthearted gaming experience.