末日街99号 is a pixel art survival strategy game set in a dystopian wasteland. Players must manage resources, construct shelters, and make critical decisions while navigating a world overrun by zombies. The game's immersive experience is built around three core gameplay elements: resource management, tactical building, and moral choices. Players explore the ruins of a collapsed civilization, gather resources, and expand their influence in a hostile environment.

In this game, players are tasked with creating a sanctuary amidst chaos, as they encounter other survivors who may either aid or betray them. Every decision affects the game's outcome, allowing for different endings based on the player's moral compass. Training armed teams, recruiting allies, and advancing technology are essential for survival. Players also interact with unique companions, each contributing to both emotional support and combat efficiency in the relentless struggle against zombie hordes.