This is the first Metal Gear game to appear on mobile devices. It is a continuation of the story from the previous Metal Gear Solid game, and introduces a new character, the main character, Venom Snake. The story is based on the events from the previous game, in which a group of people from the Military Cyber Field Operations Group 9 (MSF) was attacked by a large number of enemies, forcing the team to split up. One of them, Big Boss, is in a coma due to a previous attack.

The main character, Venom Snake, will go on a journey to seek revenge for the attack. Along the way, he will encounter various enemies and obstacles.