Memetric: Final Lifeforms is a strategy game set in a captivating sci-fi world, where players aim to restart life on a planet after a catastrophic extinction event. The gameplay is primarily sidescrolling, allowing players to acquire and breed various unique creatures, each with distinct characteristics. By investing in these creatures, players can gather raw materials like energy, which are essential for developing protective structures such as walls, lasers, and mines. The game incorporates a passive development system that tailors players' available tools based on their gameplay style.

The narrative unfolds across five interconnected terrariums, with a medium-length story complemented by side quests. Players engage with NPCs through a dynamic conversation system, where their responses can shape relationships but do not alter the game's conclusion. The overarching challenge involves defending against the Mold, an infectious threat that endangers wildlife and necessitates strategic planning and resource management.