LISA: The Painful - Definitive Edition is an RPG that immerses players in a grotesque and humorous post-apocalyptic world. Set in the desolate wasteland of Olathe, the game challenges players to navigate a landscape filled with moral dilemmas and harsh choices that impact the narrative. Players must make sacrifices to ensure the survival of their party members, facing brutal consequences along the way.

The Definitive Edition enhances the original experience with upgraded HD graphics, a 120 FPS mode, and a revamped battle system. It introduces new content, including campfire conversations among party members, new music tracks, and a music player featuring selections from LISA: The First. Additionally, players can explore new secrets and engage in the Painless (Story) mode, offering a fresh perspective on the game's dark themes.