LEGO Marvel Super Heroes offers players an engaging experience set in an original story that spans the Marvel Universe. Players can take control of iconic characters such as Iron Man, Spider-Man, Hulk, and Captain America as they unite to thwart Loki's plans alongside other villains. The game features exploration across LEGO Manhattan, allowing players to visit significant locations like Stark Tower and the X-Mansion while collecting Cosmic Bricks.

With over 100 playable Super Heroes and Super Villains, the game provides a variety of unique abilities and strengths. Players can utilize Iron Man's flight and missile capabilities, Spider-Man's web-slinging and agility, and Captain America's shield skills. The inclusion of "BIG-fig" characters like Hulk adds powerful moves and destruction to gameplay. Additionally, character customization and humorous storytelling enhance the overall LEGO videogame experience.