Last Run: Survival Fight is an engaging Android game that immerses players in strategic combat scenarios against alien enemies. The gameplay begins with pre-mission preparations where players review their troop count and available resources, such as Gold Coins. Players can invest these coins in a variety of upgrades, including enhancing weapons, recruiting additional soldiers, or purchasing temporary combat boosts to increase their squad's effectiveness in battle. The decision-making process is critical, as players must choose between two paths that can significantly affect their troop strength before entering combat.

Once the mission begins, players experience automatic combat where their squad engages enemies in a corridor setting. The game challenges players to manage their troop count effectively, as enemy fire can lead to random troop losses during engagements. This blend of preparation and real-time strategy creates a dynamic gameplay experience that keeps players engaged as they navigate through increasingly challenging levels.