Last Asylum: Plague is a strategic management game set in a world ravaged by a mysterious plague. Players assume the role of a plague doctor tasked with building and managing a sanctuary to provide refuge for the sick. The game emphasizes strategy as players must treat patients, craft remedies, and expand their facilities to accommodate the increasing number of afflicted individuals. With a focus on resource management, players will gather essential supplies to ensure the survival of their community.

In addition to managing the sanctuary, players must also defend against threats such as the Rat Swarm. This involves recruiting and upgrading heroes, constructing defensive towers, and engaging in battles to repel invaders. Players can send survivors to gather resources and reclaim abandoned towns, all while creating strategic lineups of heroes to outsmart competitors. Last Asylum: Plague combines elements of strategy, resource management, and combat in a compelling narrative about hope and survival.