Jurassic World Evolution: Secrets of Dr. Wu offers players an exciting expansion to the base game, introducing a captivating storyline centered around Dr. Henry Wu's research on hybrid dinosaurs. Set in the mysterious Las Cinco Muertes, players engage in a series of campaign missions that delve into Dr. Wu's secretive operations, providing access to hidden hybrid development facilities. The narrative unfolds in two new locations—Isla Muerta and Isla Tacano—each presenting unique challenges and opportunities.

As players collaborate with various Divisions while secretly reporting to Dr. Wu, they must earn his trust to unlock new dig sites and bring five new dinosaur species to life, including three of Dr. Wu's hybrids. This expansion not only enhances the gameplay experience with new dinosaurs but also introduces elements of conflict stemming from the intricate relationships between characters and their interests, adding depth to the simulation.