Infection Free Zone is a strategy game for PlayStation 5 that immerses players in a post-apocalyptic world where they lead a group of survivors. Players must select a base of operations and strategically adapt nearby structures to create a sustainable settlement. The game incorporates resource management and decision-making elements, requiring players to plan effectively to ensure the survival of their group against various external threats.

As night falls, the gameplay shifts into a more intense phase where players must defend their settlement from infected creatures. A standout feature of Infection Free Zone is its use of real geographical data, allowing players to set their game in any city around the globe. This feature enhances the realism and immersion, making the strategic challenges within the game feel more relevant and engaging.