Hotline Miami 2: Wrong Number is a highly anticipated sequel to the original Hotline Miami game. The game is set in 1985, during the Cold War between the Soviet Union and the United States, where military operations are taking place in Hawaii. The game's story revolves around the squad "Ghost Wolves," comprising Dan Smith, Jacket, and two soldiers. The United States is losing, and the squad is ordered to capture the most dangerous Soviet zone.

The gameplay of Hotline Miami 2: Wrong Number is similar to the first game, but with added levels of difficulty, classic and hard mode, which unlocks after beating the game on classic mode. The hard mode is more challenging and contains more dangerous opponents. The game has 13 playable characters, each with their vision of the story, similar to Jacket and Biker in the original game. The game includes masks from the first part, and new masks that offer new abilities have been added.