Griftlands is a deck-building rogue-like game set in a broken-down sci-fi world where players must navigate through challenging decisions involving combat and negotiation. Every choice made, from the jobs accepted to the alliances formed and cards collected, significantly impacts the gameplay. Despite the swift threat of death, each playthrough presents fresh scenarios and strategies waiting to be discovered.

Players can embody Sal, Rook, or Smith, each featuring a distinct campaign with specialized decks, abilities, and maps to uncover. Sal seeks profit and vengeance, Rook operates as a secretive spy with personal motives, and Smith, an unlikely hero, holds the potential to change the world. The diverse environments, factions, and locations unique to each character's story provide a rich backdrop for exploration and exploitation.