As a young man, Samer Al-Madani was inspired by his love for music, and he studied musicology in Germany. He began his music career as a keyboardist in a local band. Afterward, he joined another band as a keyboardist, but he was also capable of playing guitar and bass.

When he was 19 years old, Al-Madani joined the musical group Al-Kahramaa, which is considered one of the best Arabic music groups of all time. In the same year, he participated in his first film, Al-Mu'allim.

Al-Madani's career as a musician began to take off, and he became known as a popular musician in the Arab world. In addition, he became famous as the lead singer of a number of songs, including Al-Kahramaa's songs, and he was also known as a talented musician and songwriter. He was also known as the lead singer of the group Al-Kahramaa.

In the early 1990s, Al-Madani began to create his own songs, which were inspired by his experience and his feelings about the events that were taking place in the Middle East at the time. His songs reflected on the Arab world's recent political events, and they also talked about love and the problems that can occur in a relationship.