Gene Rain is an action game available on PlayStation 4, where players take control of a 'Death Squad' amidst global conflicts. The narrative revolves around three main characters—Alex, Salman, and Li Ying—each representing different factions with their own goals. Players engage in battles across various environments while navigating the complexities of war and strategy.

The game features a straightforward upgrading system, allowing players to enhance three primary weapons and various character attributes. Gene Rain presents four distinct scene types, including destroyed cities and dark urban landscapes, enhancing the immersive experience. With over 12 unique enemy types, the game incorporates advanced AI to simulate human-like behaviors, making encounters varied and challenging.