Football Manager 2006 is a detailed soccer management simulation that immerses players in the role of a team manager across various national championships worldwide. It features over 270,000 personalities, including players, managers, and staff, from 5,000 teams spanning 50 countries. This installment enhances the management experience with new features such as half-time team talks, an in-game tutorial, and a revamped injury module, allowing players to engage more deeply with their teams.

Additionally, the game introduces one-on-one interactions with unhappy players, manager contracts, and touchline commands to influence matches in real-time. Enhanced player statistics, including height and weight, along with referee profiles, provide greater insight into game dynamics. Instant replays allow for reviewing key moments, making Football Manager 2006 a comprehensive tool for both casual and dedicated soccer fans.