EmoPLAY is an Android application developed by Fundación Orange in the Education & Reference category. It is an innovative product aimed at children and teenagers with Autism Spectrum Disorder (ASD) that uses computer vision and machine learning techniques to capture their facial expressions and help them to modulate their emotions through an interactive game. Through a webcam placed in front of the user, the system analyzes the image in real-time to provide feedback to the user and get the modulation of their emotion through automatic feedback. The application has been trained to recognize facial expressions in users between 6 and 16 years and offers the possibility of working on learning and expressing emotions in any corner of the world and adapted to mobile devices. EmoPLAY is a product that could be applied in other disorders and has a future in the field of e-Health.