The sixth game in the Devil May Cry franchise, Devil May Cry 5, continues the plot of Devil May Cry 2.

In this game, the player will control the two main characters from the third-person perspective. 

The first is Dante, a knight whose soul was saved by the mysterious woman called V. After losing his right arm, he is given a new one made by his engineer. He is also given the ability to use a variety of different weapons, such as his sword Sparda and his mace Rebellion.

The second is Nero, a street-wise leader of a gang of devils. He has a prosthetic left arm that he uses to fight with his sword and gun Blue Rose. He is also given the ability to summon a variety of different demons and monsters to fight with.