Destroy All Humans is a faithful remake of the classic action-adventure game that allows players to step into the shoes of the alien Crypto-137. Set in the 1950s, players can terrorize humanity, harvesting DNA and using a variety of alien weaponry and psychic abilities to wreak havoc. The game features an array of unique weapons, including the infamous Anal Probe Gun, and allows players to infiltrate human society by posing as one of them. The vibrant cities of 1950s America are fully explorable, offering diverse environments that enhance the gameplay experience.

This remake has been meticulously rebuilt from the ground up, ensuring that both longtime fans and newcomers can enjoy its humor and action. Players can utilize psychokinesis to manipulate objects and enemies, and even pilot a flying saucer to obliterate human structures. Additionally, the game includes the previously unreleased Lost Mission of Area 42 and a Skin Pack DLC, adding extra content for an even more engaging experience.