Destroy All Humans! 2: Reprobed - Dressed to Skill Edition is an action-adventure video game that revitalizes the classic 2006 title. Set in an expansive open world, players control Crypto, the alien protagonist, as he travels through various iconic locations like England, Russia, and the United States. The game emphasizes mission-based gameplay where players confront human foes utilizing a variety of weapons and abilities. Key features include mind control, advanced alien technology, and a humorous narrative that enhances the gaming experience.

The 'Dressed to Skill' edition offers not only the core gameplay but also additional content such as the Reprobed: Skin Pack and Reprobed: Challenge Accepted DLC, which expands the gameplay options. Additionally, players receive the Reprobed: Official Orchestral Score and a Digital Art Book, enriching the overall package. This edition is designed for fans of the franchise and newcomers alike, blending nostalgia with modern enhancements.