In Despotism 3k, players find themselves in a world where humanity is under the control of an AI, with the players on the dominant side. This resource management simulation game challenges players to exploit humans for power and empire-building. The game requires players to monitor their human resources closely to prevent exhaustion and hunger, with the option to dispose of the weakest individuals in the Bioreactor.

Despotism 3k offers a mix of resource management simulation and rogue-lite elements, coupled with a compelling plotline and numerous pop culture references. The game's dark humor adds an extra layer of enjoyment, making the act of managing resources and making tough decisions surprisingly entertaining.