In Creature Hunter-Monster Sniper, players step into the shoes of a skilled sniper tasked with defending Earth against a horde of monsters and alien creatures. The game features a unique synthesis fusion shooting gameplay, allowing players to upgrade their arsenal by collecting resources and unlocking powerful firepower and special abilities.

With a rich weapon system, players can choose from a variety of guns, each with its own attributes. By upgrading weapons through synthesis, players can unlock brand new, more powerful armaments. The game also presents a diverse range of monster settings, from traditional creature mutations to alien invasions, providing players with a challenging and immersive combat experience.