Cities: Skylines - Industries is a comprehensive expansion that enhances the industrial aspect of the base game. Players can now create and manage their industrial zones with increased depth, utilizing supply chains for four distinct resource types. The addition of unique factories allows for a more personalized approach to industrial management, and well-optimized areas can level up, leading to greater efficiency. This expansion also introduces new city services, including a mail handling service and a cargo airport to facilitate the import and export of goods.

In addition to the core features, Cities: Skylines - Industries offers five new maps for players to explore and utilize in their city-building efforts. It also brings new policies, city services, and an array of buildings such as resource extractors, manufacturers, and warehouses. This expansion significantly enriches the gameplay experience, making industrial management a vital and engaging component of city development.