In this BEN 10 XENODROME PLUS game, players take on the role of Ben Tennyson. Here, users must utilize his alien powers to combat intergalactic threats. With a unique puzzle-style battle system, players can unleash their favorite aliens from the Ben 10 Ultimate Alien TV series and level them up to take down villains like Aggregor.

The game features a reflex-based puzzle mechanic, where timing is crucial in selecting actions and utilizing a tag-team system. With various game modes, including arcade and survival, players can challenge AI opponents and test their skills. The game offers a wide range of alien forms to play as, each with their own powers, and includes a large roster of characters to battle against.