Set in 1751 North America during the French and Indian War, Assassin's Creed Rogue follows the story of Shay Patrick Cormac, a young Assassin who undergoes a dark transformation after being betrayed by his own order. As Shay, players experience the journey from Assassin to Assassin Hunter, exploring locations like New York City, the wild river valley, and the North Atlantic. The game introduces a new perspective, delving into the life of a character turned rogue in the Assassin's Creed franchise.

In Assassin's Creed Rogue, players immerse themselves in Shay's quest for vengeance against those who betrayed him, shaping the future of the brotherhood. With a focus on Shay's evolution and the intense hunt for Assassins, the game offers a unique narrative within the Assassin's Creed universe.